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Valproic acid in prophylaxis of bipolar affective disorder: A case of valproate encephalopathy: Nervenarzt Vol 71(5) May 2000, 401-403.

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Increased frequencies of sister chromatid exchange (SCE) have been reported in a study of epileptic children taking valproate, but this association was not observed in another study conducted in adults.

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Extracted data consisted of study characteristics (such as treatments and doses, method for diagnosis of generalised anxiety disorder, duration, and study location) and relevant outcomes (such as anxiety scores at baseline and end of study, and proportions of responders and remitters) (see table A on bmj.

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Comorbidity of anxiety disorders in patients with remitted bipolar disorder.

To prevent major seizures, valproate should not be discontinued abruptly, as this can precipitate status epilepticus with resulting maternal and fetal hypoxia and threat to life.

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Reduced valproate plasma levels possible after introduction of efavirenz in a bipolar patient: Bipolar Disorders Vol 8(4) Aug 2006, 415-417.

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Jerry Kennard, psychologist and Associate Fellow and Chartered member of the British Psychological Society, provides some expertise and insight into the diagnosis and treatment of Bipolar Disorder.

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The primary findings were an increase in the incidence of subcutaneous fibrosarcomas in high-dose male rats receiving valproate and a dose-related trend for benign pulmonary adenomas in male mice receiving valproate.

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RL was involved in finalising the scope of the analyses, first and second pass screening of articles, and data selection stages of the systematic review.

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McCabe PH, Michel NC, McNew CD, Lehman EB ( 2006) Conversion from delayed-release sodium valproate to extended-release sodium valproate: initial results and long-term follow-up.

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