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About 12 years ago my doctor found out that the level of uric acid in my blood was above normal. Soon afterwards I started having gout attacks and felt myself an old helpless ass. But my doc, a nice young lady, prescribed me with Allopurinol. It has been 10 years since I started taking the pills and I'm still damn grateful to my wonderful doctor!



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I've had undisguised symptoms for 20 year causing mild discomfort e.g. Uric acid buildup on earlobes. Chronic wrist pain. Moderate two attacks , all annoying but I never figured it to be gout or realize the horror about unleash itself on me at a fit 49 years old. I exercise, only about 10 lbs overweight and eat healthy. I was a heavy beer drinker though. Last year my left wrist and thumb swoll to the size of a red grotesque boxing glove. No pain medication could touch it. Imagine bone fracture pain with no relief. I was in chronic pain, depressed despondent and close to suicidal. Because I had ignored symptoms for so long the rheumatologist told me I had "entrenched" gout and the allopurinol was going to make it worse before it got better.

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Allopurinol 300 mg daily probably does not reduce the incidence of acute gout attacks when compared with placebo over 30 days, and allopurinol 100 to 600 mg daily may not reduce acute gout attacks compared with benzbromarone 100 to 200 mg daily or febuxostat 80 mg daily over 16 to 24 weeks.

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Single studies reported no difference in pain reduction when allopurinol (300 mg daily) was compared with placebo over 10 days, and no difference in tophus regression when allopurinol (200 to 300 mg daily) was compared with febuxostat (80 mg daily).

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Allopurinol no puede ser usadopor pacientes con hipersensibilidad a la medicación, por individuos con desordenes hepáticos o reñales, hemochromatosis primario, asymptomatic hyperuricemia, gota aguda, embarazo, lactancia.

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These tables provide key information concerning the quality of evidence, the magnitude of effect of the interventions examined and the sum of available data on our seven main outcomes (participant-reported reduction in acute gout attack frequency, proportion of participants achieving a target serum urate level, joint pain reduction, function, tophus regression, number of study participant withdrawals due to AEs and SAEs), as recommended by The Cochrane Collaboration ().

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Dintre acestea se folosesc: acidul oro-tic, care blocheaza acidul uric; inhibitorii xantinoxidazei, care se administreaza in doze de 100 mg zilnic (uneori 400 mg), sub forma de alopurinol (Zyloric sau Milurit) si tiopurinol.

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